UMBC College of Engineering and Information Technology
Chemical, Biochemical & Environmental Engineering


PDF reprints are available upon request to Jennie Leach

Peer-Reviewed Manuscripts


Balasubramanian S, JA Packard, JB Leach, EM Powell. (2016) Three-dimensional environment sustains morphological heterogeneity and promotes phenotypic progression during astrocyte development. Tissue Engineering 22:885-898. [PMID: 27193766] (Featured on cover, see image at right.)

Tissue Engineering
35. Ghourichaee SS, JB Leach. (2016) Synergistic effects of substrate and hypoxia on human neural stem cell proliferation. Journal of Materials Chemistry B 4:3509-3514. [link]
34. Leach JB, MS Shoichet. (2015) Naturally-derived and bioinspired materials. Journal of Materials Chemistry B. 3:7814-7. [link]

Neuromethods: Extracellular Matrix, (2015) Editors: Jennie B. Leach and Elizabeth Powell, publisher: Springer Protocols, Humana Press. [link]


Balasubramanian S, EM Powell, JB Leach. (2015) Culturing Neurons, Glia and Progenitor Cells in Three-Dimensional Hydrogels. Neuromethods: Extracellular Matrix, Editors: Jennie B. Leach and Elizabeth Powell, publisher: Springer Protocols, Humana Press, 93: 91-99. [link]


Balasubramanian S, EM Powell, JB Leach. (2015) Investigating Cell-ECM Interactions and ECM Synthesis in Three-Dimensional Hydrogels. Neuromethods: Extracellular Matrix, Editors: Jennie B. Leach and Elizabeth Powell, publisher: Springer Protocols, Humana Press, 93: 101-109. [link]


Schoukroun-Barnes LR, S Wagan, J Liu, JB Leach, RJ White. (2013) Biocompatible Hydrogel Membranes for the Protection of RNA Aptamer-Based Electrochemical Sensors. Proceedings of SPIE, SPIE Defense, Security + Sensing, 8719-18. [link]


Ribeiro A, S Balasubramanian, D Hughes, S Vargo, E Powell, JB Leach. (2013) β1-integrin Cytoskeletal Signaling Regulates Sensory Neuron Response to Matrix Dimensionality. Neuroscience 248:67-78. [PMID: 23764511]


Zustiak SP, S Pubill, A Ribeiro, JB Leach. (2013) Hydrolytically degradable poly(ethylene glycol) hydrogel scaffolds as a cell delivery vehicle: Characterization of PC12 cell response. Biotechnology Progress 29:1255-64. [PMID: 24474590]

27 Wang L, MA Acosta, JB Leach, R Carrier. (2013) Spatially monitoring oxygen level in 3D microfabricated cell culture systems using optical oxygen sensing beads. Lab on a Chip 13:1586-92. [PMID: 23443975]
26 Zustiak SP, Y Wei, JB Leach. (2013) Protein-hydrogel interactions in tissue engineering: mechanisms and applications. Tissue Engineering Part B: Reviews 19:160-71. [PMID: 23150926]
25 Acosta MA, M Velasquez, K Williams, JM Ross, JB Leach. (2012) Fluorescent silica particles for monitoring oxygen levels in three-dimensional heterogeneous cellular structures. Biotechnology & Bioengineering 106:2663-70. [PMID: 2251120]
24 Guo D, X Chen, S Vadala, J Leach, Y Kostov, W Bewley,C Kim, M Kim, C Canedy, C Merritt, I Vurgaftman, J Meyer, F Choa. (2012) Neuron Absorption Study and Mid-IR Optical Excitations. Proceedings of SPIE, Photonics West BiOS, 8207G-156. [link]
23 Ribeiro A, S Vargo, E Powell, JB Leach. (2012) Substrate three-dimensionality induces elemental morphological transformation of sensory neurons on a physiologic timescale. Tissue Engineering 18:93-102. [PMID: 21910606]
22 Zustiak S, JB Leach. (2011) Characterization of Protein Release from Hydrolytically Degradable Poly(ethylene glycol) Hydrogels. Biotechnology & Bioengineering 108:197-206. [PMID: 20803477]
21 Reeves R, A Ribeiro, Lombardo L, R Boyer, JB Leach. (2010) Synthesis and enzymatic degradation of carboxymethylcellulose-methacrylate hydrogel cell scaffolds. Polymers MDPI 2(3): 252-264. [PMID: 22708058]
20 Zustiak S, H Boukari, JB Leach. (2010) Solute Diffusion and Interactions in Cross-Linked Poly(ethylene glycol) Hydrogels Studied by Fluorescence Correlation Spectroscopy. Soft Matter 6:3609-18. [PMCID: 3057087].
19 Zustiak S, R Durbal, JB Leach. (2010) Covalent Incorporation of Cell-Adhesive Peptide Ligands into Poly(ethylene glycol) Hydrogels Influences Physical, Mechanical and Transport Properties. Acta Biomaterialia 6:3404-14. [PMID: 20385260]
18 Zustiak S, JB Leach. (2010) Hydrolytically Degradable Poly(Ethylene Glycol) Hydrogel Scaffolds with Tunable Degradation and Mechanical Properties. Biomacromolecules 11(5):1348–1357. [PMID: 20355705]
17 Leach JB, EM Powell. (2010) Understanding hypoxic environments – Biomaterials approaches to neural stabilization and regeneration after ischemia. In Studies in Mechanobiology, Tissue Engineering and Biomaterials, Vol 2: Biomaterials as Stem Cell Niche, 247–274. [DOI]
16 Leach JB, AKH Achyuta, S Murthy. (2010) Bridging the Divide Between Neuroprosthetic Design, Tissue Engineering and Neurobiology. Frontiers in Neuroengineering 2:article 18, doi: 10.3389/neuro.16.018.2009 [PMID: 20161810]
15 Acosta M, P Ymele-Leki, Y Kostov, JB Leach. (2009) Fluorescent microparticles for sensing cell microenvironment oxygen levels within 3D scaffolds. Biomaterials 30:3069-74. [PMID: 19285719]
14 Williams C, J Liao, EM Joyce, JB Leach, MS Sacks, JY Wong. (2009) Changes in structural and mechanical properties in decellularized arteries: Implications for vascular tissue engineering. Acta Biomaterialia 5:993-1003. [PMID: 19135421]
13 Sarkar S, BC Isenberg, E Hodis, JB Leach, TA Desai, JY Wong. (2008) Fabrication of a layered microstructured polycaprolactone construct for 3-D tissue engineering. J Biomater Sci Polym Edn 19:1347-1362. [PMID: 18854127]
12 Leach JB, XQ Brown, JG Jacot, PA DiMilla, JY Wong. (2007) Neurite outgrowth and branching of PC12 cells on very soft substrates sharply decreases below a threshold of substrate rigidity. Journal of Neural Engineering 4:26-34. [PMID: 17409477]
11 Koester S, JB Leach, B Struth, T Pfohl, JY Wong. (2007) Visualization of type I collagen self-assembly induced by tunable pH gradients. Langmuir 23:357-359. [PMID: 17209575]
10 Leach JB (2006). Tissue-Engineered Peripheral Nerve. In: Encyclopedia of Biomedical Engineering, editor: Metin Akay, publisher: Wiley, 6: 3568-3578.
9 Leach, JB, JB Wolinsky, P Stone, JY Wong. (2005) Crosslinked alpha-elastin biomaterials: Towards a processable elastin mimetic scaffold. Acta Biomaterialia 1:155-164. [PMID: 16701792]
8 Leach JB, CE Schmidt (2005). Characterization of protein release from photocrosslinkable hyaluronic acid-polyethylene glycol hydrogels. Biomaterials 26:125-135. [PMID: 15207459]
7 Wong JY, JB Leach, XQ Brown (2004). Balance of chemistry, topography, and mechanics at the cell-biomaterial interface: Issues and challenges for assessing the role of substrate mechanics on cell response. Surface Science 570:119-133. [DOI]
6 Leach JB, KA Bivens, CN Collins, CE Schmidt (2004). Development of photocrosslinked hyaluronic acid-polyethylene glycol-peptide composite hydrogels for soft tissue engineering. Journal of Biomedical Materials Research 70A:74-82. [PMID: 15174111]
5 Baier Leach J*, CE Schmidt (2004). Hyaluronan. In: Encyclopedia of Biomaterials and Biomedical Engineering, editors: GE Wnek, GL Bowlin, publisher: Marcel Dekker, p. 779-89.
4 Baier Leach J*, KA Bivens, CW Patrick, Jr., CE Schmidt (2003). Photocrosslinked hyaluronic acid hydrogels: natural, biodegradable tissue engineering scaffolds. Biotechnology & Bioengineering 82:578-89. [PMID: 12652481]
3 Schmidt CE, J Baier Leach* (2003). Neural tissue engineering: strategies for repair and regeneration. Annual Review of Biomedical Engineering 5:293-347. [PMID: 14527315]
2 Fischbeck JA, JM Baier*, R Akella, D Hern-Anderson, CE Schmidt (2001). Genetic modification of alpha-Gal expression in xenogeneic endothelial cells yields a complex immunological response. Tissue Engineering 7:743-56.  [PMID: 11749731]
1 Schmidt CE, JM Baier* (2000). Acellular vascular tissues: natural biomaterials for tissue repair and tissue engineering. Biomaterials 21:2215-31. [PMID: 11026628]

*Jennie B. Leach is also listed as J.M. Baier and J. Baier Leach.

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